First of all, look critically at your current CV. Are there any obvious mistakes or omissions: dates of employment that are not consecutive; spelling mistakes; incomplete entries? Correct them now.
Is your CV just a list of responsibilities from your job description? This is unforgiveable and very evident. Your CV must state your own achievements and deliverables in your current and most recent positions. Where these are easily quantifiable, have you included them in this way, e.g. 500 patients recruited 2 months ahead of schedule; staff retention at 95% for over 3 years, 4 global database locks achieved ahead of schedule?
Create a short concise profile promoting yourself and outlining what you seek in terms of location, work scope, responsibility, demonstrate enthusiasm for your subject or current issues prevailing. Be prepared to adapt your CV introduction for each relevant role.
Details differentiate you from others. Add regional terminology e.g. global vs. domestic, country coverage, Phases; clarify your competence level and aspirations in a new role, cite awards or contract extensions you have had. If you’re 'contract' not permanent, then say so - misleading people is a sign of underhand tendencies.
Is your CV full of your current company’s acronyms and abbreviations, e.g. PRD, PDOA, GCO? If so, take these out and use generally accepted terms.
If your CV is too long, take out the detail in any role that you held more than 8 years ago.